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Xenical May Have Role In Long-Term Management of Obesity

Clinical data presented today at the North American Association for the Study of Obesity (NAASO) Annual Meeting show that Hoffman-La Roche's Xenical(R) (orlistat) may be effective for the long-term management of obesity. Researchers presented results from several abstracts on Xenical, which is being investigated to promote weight loss, weight maintenance and reduction in the risk of weight regain and to improve obesity-related disease factors when compared to diet alone. Approximately 58 million, or one-third of American adults are overweight or obese. Among adults, the incidence of obesity has increased from 25 to 32 percent in the last 10 years. Obesity is second only to smoking as a cause of preventable death in the US, and is a major contributing factor to serious medical conditions such as diabetes, hypertension and other cardiovascular diseases. Xenical is the first of a new class of non-systemic anti-obesity drugs called lipase inhibitors which act in the gastrointestinal tract to prevent the absorption of fat by about 30 percent. Drugs in this class do not achieve their effect through brain chemistry. Roche originally submitted a New Drug Application (NDA) for Xenical in 1996. An FDA Advisory Committee unanimously recommended approval of Xenical on May 14, 1997. Roche later withdrew its original NDA to conduct further analyses of data at the request of the FDA. Hoffmann-La Roche expects to resubmit the NDA for Xenical within a few days.

ESC CONGRESS: Xenical Plays Important Role In Cardiovascular Risk Reduction

According to a leading Canadian researcher, Xenical, a recently-approved prescription medication for weight loss, in combination with a mild calorie-reduced diet can significantly reduce the risk of cardiovascular disease in obese patients. In clinical trials, patients on Xenical showed significant reductions in cholesterol, insulin and glucose levels, as well as in blood pressure, which are all important causes of cardiovascular disease.

Xenical May Have Role In Long-Term Management of Obesity

Clinical data presented today at the North American Association for the Study of Obesity (NAASO) Annual Meeting show that Hoffman-La Roche's Xenical(R) (orlistat) may be effective for the long-term management of obesity. Researchers presented results from several abstracts on Xenical, which is being investigated to promote weight loss, weight maintenance and reduction in the risk of weight regain and to improve obesity-related disease factors when compared to diet alone. Approximately 58 million, or one-third of American adults are overweight or obese.
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